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2026-03-17 09:48:45
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Company
Dividend payout for Pfizer is 12.48 million won
by
Chon, Seung-Hyun
Apr 15, 2022 06:03am
Pfizer Pharmaceutical Korea performed better last year with sales of the COVID-19 vaccine, but its dividend was only 12.48 million won. Regardless of the sharp rise in performance, the dividend payout ratio was only 0.01%, allocating 20% of the capital of preferred stocks. It has adhered to a unique dividend policy that distributes 12.48 million won in total except for twice in the past 20 years. According to the Financial Supervisory Service on the 14th, Pfizer Korea decided to pay 12.48 million won in dividends last year. Dividends have been set at 12.48 million won for the fourth consecutive year since 2018. Although its performance improved significantly with the COVID-19 vaccine last year, dividends were calculated on the same scale as before. Pfizer Korea's sales soared more than four times from 391.9 billion won in 2020 to 1.694 trillion won last year. The amount is more than twice as much as 751.6 billion won recorded in 2017 before Pfizer Korea spun off with Viatris. Pfizer's performance soared as it supplied the COVID-19 vaccine developed with Germany's BioNTech. Pfizer Korea recorded an operating loss of 7.2 billion won in 2020, with its operating profit rising to 59.2 billion won last year. Net profit reached 95.9 billion won last year. The sale of land and buildings at its headquarters in Jung-gu, Seoul, generated 44.4 billion won in profits from disposal of tangible assets, further expanding its net profit. Dividends paid to shareholders are proportional if a company's net profit surges, but it is interesting that last year's dividend of Pfizer Korea was set at 12.48 million won, the same as the previous year. The dividend payout ratio stood at only 0.01 %. Pfizer Korea calculated dividends by applying a dividend rate of 20% to preferred stock capital. Pfizer Korea has a total capital of 922.92 million won. Among them, common stock capital is 860.52 million won and preferred stock capital is 62.4 million won. Dividends of 12.48 million won were set at 20% of 62.4 million won in preferred stock capital. The largest shareholder of Pfizer Korea is Pfizer's Dutch subsidiary 'PFG South Korea 1 B.V.' with a 97.15% stake. Pfizer Korea issued a total of 12.8 million preferred shares. Among them, PFOFG South Korea 1 B.V. holds 7,280 shares, while domestic shareholders hold the remaining 5,200 shares. PFOFG South Korea 1 B.V. and domestic shareholders receive 7.28 million won and 5 million won in dividends from Pfizer, respectively. As of the end of November 2020, the capital of Pfizer Korea was 12.08 billion won. However, the capital was reduced to 922.92 million won as the extraordinary shareholders' meeting at the end of 2020 decided to incinerate 2,233,416 shares for a fee of 61,000 won per share owned by ordinary shareholders. Preferred stocks did not change, so the same dividend as the previous year was set according to the dividend calculation standard of "20% preferred stocks." For 20 years since 2002, Korea Pfizer has been paid 12.48 million won in dividends on the same basis of 20% of preferred stocks except for No. 2. In 2017, dividends were set at 79.794 billion won, more than net profit. At that time, both common stocks (2,455,520 shares) and preferred stocks (12,480 shares) decided to pay 660% of the par value of 5,000 won as a dividend rate, expanding the amount of dividends. In 2008, a dividend of 190 billion won was set. Even though it recorded a deficit of 600 million won at the time, high dividends were confirmed as it decided a dividend rate of 3045% compared to its face value. In the past 20 years, only two high dividends have been set, and the rest have continued to have a small dividend policy of 12.48 million won. In other words, the headquarters made profits by making high dividends once a decade on average. An official from Pfizer Korea said, "We cannot disclose the background of the dividend decision." Pfizer
Company
Acromegaly drug ‘Somavert’ lands in ‘Big 5’ hospitals
by
Eo, Yun-Ho
Apr 15, 2022 06:03am
The new acromegaly drug ‘Somavert’ may now be prescribed at general hospitals in Korea. According to industry sources, Pfizer Korea’s Somavert (pegvisomant) has passed the review of Drug Committees at the ‘Big 5’ tertiary hospitals in Korea including the Samsung Medical Center, Seoul National University Hospital, Seoul St.Mary’s Hospital, Asan Medical Center and Shinchon Severance Hospital. The drug can now be prescribed at most major hospitals in Korea. As Somavert has been listed for insurance benefit in September last year, no barriers remain in patients' access to the drug. Acromegaly, which is also known as giantism, is a rare condition characterized by the excessive secretion of growth hormones that causes abnormal, excessive secretion of IGF-I, and is most often caused by a benign tumor of the pituitary gland. Acromegaly is associated with clinical changes including reduced life expectancy, cardiovascular issues, enlargement of hands, feet, and other organs, facial deformity, fatigue, joint pain, metabolic disorder, etc. In such cases, the mortality rate is twice or even three times higher than normal people. Also, as the physical deformities do not return to normal, early diagnosis and treatment are very important. Somavert’s efficacy was demonstrated in the randomized, double-blind, pivotal SEN-3614 study that was conducted on 112 patients with acromegaly for 12 weeks. The 112 patients were randomly assigned to receive 10mg, 15mg, and 20mg of pegvisomant or placebo every day, and its primary efficacy endpoint was the percent change in serum IGF-I concentration from baseline to Week 12. Study results showed that in Week 12, the median serum IGF-I concentration reduction level was 16.8%, 26.7±27.9%, 50.1±26.7%, 62.5±21.3% for the placebo arm, and 10mg, 15mg, 20mg pegvisomant arm, respectively. In other words, Pegvisomant significantly reduced serum IGF-I concentrations in all three doses compared to placebo. The rate of patients whose serum IGF-I concentrations normalized compared to baseline were 10%, 54%, 81%, and 89% for the placebo arm and 10mg, 15mg, and 20mg pegvisomant arm, respectively. Pegvisomant showed a significantly higher rate in all three doses compared to placebo. Meanwhile, Somavert was approved for the treatment of adult patients with acromegaly who have had an inadequate response to surgery and/or radiation therapy and in whom an appropriate medical treatment with somatostatin analogues did not normalize IGF-I concentrations or was not tolerated in September last year and designated an orphan drug in 2018.
Company
Artiva expands contract to develop dell therapy with MSD
by
Eo, Yun-Ho
Apr 15, 2022 06:03am
GC Pharma affiliate Artiva Biotheraputics announced on the 12th that it has signed a contract with MSD to expand the development of natural killing (NK) cell therapy. Artiva was established in 2019 by GC CELL and GC LABTECH in San Diego, USA. Under the contract, the two companies will promote joint research on anticancer drugs that combine NK cell therapy AB-101 under development with Tri-Specific NK-Cell Engagers owned by MSD. In particular, this contract was signed by Artiva in January last year after exporting platform technology worth KRW 2 trillion to MSD with GCELL. Artiva is already jointly developing three "CAR-NK cell treatments" for MSD and solid cancer treatment. The triple-specific NK cell-binding antibody of MSD used in this combination therapy is combined with cancer cells and specific antigens expressed in NK cells, and then activates NK cells to directly kill cancer cells, as well as activates other immune cells around cancer cells to remove cancer. Artiva's AB-101 is one of the NK cell pipelines derived from homeostatic cord blood based on GC cell technology. Artiva was approved by the FDA in December 2020 and is conducting phase 1 and 2 clinical trials for patients with recurrent and intractable B-cell lymphoma in the United States. Peter Flynn, Artiva co-founder said, "We have built a fantastic partnership with MSD over the past year. We are pleased to extend our partnership to include the development of our homologous NK cell therapy-based triple antibody candidate material."
Company
Somavert for terminal hypertrophy can be prescribed at Big 5
by
Eo, Yun-Ho
Apr 14, 2022 05:56am
Somavert, a new drug for terminal hypertrophy, can be prescribed at a general hospital. According to related industries, Pfizer Korea's Somavert has currently passed DC of the Big 5 higher-level medical institutions such as Samsung Medical Center, Seoul National University Hospital, Seoul St. Mary's Hospital, AMC, and Sinchon Severance Hospital. Currently, it can be prescribed in most major hospitals nationwide. Somavert has been listed on the insurance benefit list since September last year, making it easy to access patients. Somavert demonstrated its validity through a SEN-3614 study, a 12-week randomized, double-blind core study in 12 patients with terminal hypertrophy. 112 patients were randomly assigned to the Pegvisomant daily administration group of 10 mg, 15 mg, and 20 mg and placebo administration group, respectively, and the primary validity evaluation variable in the study was a change in serum IGF-I concentration at 12 weeks compared to the baseline. As a result of the study, the median serum IGF-I concentration at 12 weeks compared to the baseline was 4.0±16.8%, 26.7±27.9%, 50.1±26.7%, and 62.5±21.3%, respectively, in the placebo, 10 mg daily, 15 mg, and 20 mg administration groups. The proportion of patients whose serum IFG-I concentration returned to normal to baseline in the placebo-administered group, the Pegvisomant daily 10 mg-administered group, the 15 mg-administered group, and the 20 mg-administered group were 10%, 54%, 81%, and 89%, respectively, indicating that Pegvisomant was significantly higher in all three doses compared to the placebo Somavert did not respond appropriately to surgery and radiation therapy, and was approved in Korea in September last year for the treatment of adult terminal hypertrophy patients with insulin-like growth factor-I (IGF-I) concentration or intolerance due to Somatostatin mitosis treatment.
Company
“NOAC Eliquis is safe for use in high-risk groups”
by
Apr 13, 2022 06:02am
The bleeding safety of the novel oral anticoagulant (NOAC) ‘Eliquis (apixaban)’ was reaffirmed through clinical practice guidelines of major academic societies. On the 12th, BMS Korea and Pfizer Korea announced that they have hosted a ‘VMC Master of Masters Webinar’ on the 11th to share the latest advances in preventive therapies for atrial fibrillation and Eliquis’ effect and safety with healthcare professionals in Korea. The webinar was prepared to share the latest advances in stroke prevention for atrial fibrillation patients by sharing the revised clinical practice guidelines from major international societies, and highlighted the stroke prevention effect and bleeding safety of Eliquis. Professor Gregory YH Lip at the University of Liverpool, Professor Jan Steffel at the University of Zurich, and Professor Eue-Keun Choi of the Cardiology Department at Seoul National University Hospital participated as lecturers to introduce the updated guidelines of the ▲European Society of Cardiology (ESC), ▲European Health Rhythm Association (EHRA), and ▲Asia-Pacific Heart Rhythm Society (APHRS). According to Professor Steffel, the EHRA revised its guidelines last year to mention apixaban as one of the preferred NOACs in patients weighing less than 60kg, as it has shown consistent effect and safety compared to VKA in low-weight patients. Apixaban was also mentioned as a NOAC that reduced the risk of major bleeding in high-risk patients such as the elderly and patients with renal impairment. Professor Steffel added, "Special attention is required during anticoagulation therapy, especially in underweight patients, as such treatments are frequently accompanied by conditions that can increase the risk of stroke and bleeding, such as advanced age, cancer, and decreased renal function." Professor Lip introduced an integrated atrial fibrillation management strategy based on ESC guidelines. The integrated management of atrial fibrillation in the ‘Atrial fibrillation Better Care (ABC)’ pathway defines the use of anticoagulant therapy to prevent strokes as the first treatment step. Professor Lip said, “ESC is recommended over non-vitamin K antagonist oral anticoagulants or VTKs in patients with atrial fibrillation that can be administered oral anticoagulants.” Professor Choi highlighted stroke prevention therapy in Asian patients with atrial fibrillation and the use of NOACs in specific patient groups. Professor Choi said, “Patients after atrial fibrillation diagnosis grow older and develop comorbidities such as heart failure, high blood pressure, and diabetes, which continuously increases the risk of strokes. This is why the APRHS guidelines recommend patients to reevaluate their risk of strokes every 4 months.” In particular, Professor Choi focused on the stroke prevention therapies that were newly added for specific patient groups such as those with old age, underweight, liver failure, etc in the updated guidelines. Analysis of major clinical data on 4 types of NOAC (apixaban, dabigatran rivaroxaban, edoxaban) by age showed that apixaban was the only drug to show a reduction in risk of stroke, major bleeding, and intracranial hemorrhages in those between 65 to 74 and over 75 years of age compared to warfarin. On this, Choi said, “The company has steadily accumulated clinical data on various patient groups for Eliquis. The clinical practice guidelines on atrial fibrillation were updated based on real-world data on Eliquis that shows that the drug has consistent effect and safety profile even in specific patients groups, including high-risk group and Asians.”
Company
Propecia is sold in a new package
by
Apr 13, 2022 06:02am
Organon Korea announced on the 11th that it will introduce a new package of the oral male hair loss treatment Propecia (Finasteride). As for the new package, it applied CI of Organon Korea company. Propecia, which has been sold by MSD Korea for more than 20 years since its launch in Korea in 2000, was officially launched and relocated by Organon Korea, which was spun off from MSD in June last year. Organon will consolidate its position as a major product, Propecia, with its new package. Currently, Propecia is on sale in two packaging specifications: 28 tablets and 84 tablets. Organon Korea will supply changed packages for Propecia 84 tablets first in April, and will supply 28 tablets sequentially from May. Depending on the pharmacy, It sells new packages as the old packages are sold depending on the pharmacy. Han Soo-young, head of marketing at Organon Korea's Propecia, said, "This package change means that Propecia is once again announcing its official departure as a major item of Organon, and only the company name has been changed, but the quality of Propecia's production and packaging is the same as before, and Organon Korea Propecia is the No. 1 oral hair loss treatment in Korea, and we will continue to strive for its original value."
Company
KRPIA BOD meets Oh Chang-hyun, the new head
by
Eo, Yun-Ho
Apr 12, 2022 06:05am
KRPIA BOD will hold its first face-to-face meeting with Oh Chang-hyun, director of the MOHW's insurance pharmaceutical dept. According to related industries, KRPIA Board of Director (BOD) will hold a meeting with Oh Chang-hyun, the new manager, and members of the MOHW's Insurance and Pharmaceutical Affairs on the 15th. The meeting is expected to be accompanied by Oh Dong-wook, CEO of Pfizer Korea, Lee Young-shin, a full-time vice chairman of KRPIA, and some members of the board of directors. Through the discussion meeting, KRPIA BOD is a plan to deliver grievances, policies, and pledges from the perspective of pharmaceutical companies within the agenda of "expanding new drug coverage." As the industry has recently emphasized the need for the introduction of the "post-evaluation of lights" system, it remains to be seen how to proceed with discussions with the changed head of the insurance drug department. KRPIA is also discussing with the 20th Presidential Transition Committee to expand the guarantee of new drugs.
Company
No. of employees decline sharply due to restructuring/reorgs
by
Apr 12, 2022 06:04am
The number of employees at multinational pharmaceutical companies has declined sharply due to their active restructuring and reorganizations. Over 200 employees have been laid off in just 4 companies - Roche Korea, Lilly Korea, Sanofi-Aventis Korea, and Zuellig Pharma Korea. According to the Financial Supervisory Service, the number of employees at Roche Korea, Lilly Korea, Sanofi-Aventis Korea, and Zuellig Pharma Korea was 1,109, which was a 16% decrease from the 1,326 of the previous year. Approximately 80 employees left Sanofi-Aventis Korea last year. The number of employees in the company had been 492 at the end of 2020 but was reduced to 413. In the same period, the number of Zuellig Pharma Korea employees decreased by 58, from 293 to 235. Roche Korea’s employees decreased by 52 from 309 to 257. Lilly Korea’s employees decreased by 28 from 232 to 204. The companies above have all actively carried out restructuring and reorganizations last year, influenced by the business model reorganizations conducted to remove or reduce non-core departments by the companies’ global headquarters. Also, the sales department became the main target of restructuring due to the increasing preference for online-based, non-face-to-face sales activities due to COVID-19. The number of employees at Sanofi-Aventis Korea decreased greatly following the split-off and merger of its consumer healthcare business with Opella Healthcare Korea. Before the spilt-off, the company had also offered an early retirement program for its CHC and GenMed divisions. The GenMed division is in charge of non-core prescription drugs of the company other than vaccines (Pasteur), and specialty care (Genzyme). Zuellig Pharma Korea had reduced the number of employees while withdrawing its local pharmacy retail business. The company had notified employees of its plans to dissolve the pharmacy retail business and large-scale restructuring in March last year. The company had decided to undergo such measures due to continuous operating deficits brought on by the lower distribution fees and intensified market competition. The company aimed to lay off about 80 people by eliminating direct sales and leaving only a small number of personnel in online sales services, Lilly Korea had downsized its offline sales services while increasing its online sales. For this, the company had carried out a large-scale ERP since November 2020. At the time, the company explained that its purpose was “The purpose of the reorganization is to increase the productivity and efficiency of the sales division and reinforce various multi-channels including digital programs.” The company had expected 25% of the 100-something employees in its sales division to opt for the ERP, and it is analyzed that a corresponding number of employees have voluntarily retired. Roche Korea had also conducted two ERPs at the end of 2020 and in the previous year. The main subject of the ERP was the sales department. Although around 20% of the 60-70 workforce in sales were expected to opt for ERP, the number that left had exceeded expectations. The number of employees at Roche Korea, which had exceeded 300, was reduced to 250 after ERP.
Company
Lutathera’s partner ‘LysaKare’ may be prescribed at GHs
by
Eo, Yun-Ho
Apr 11, 2022 05:58am
‘LysaKare’, the drug concomitantly used with the neuroendocrine tumor treatment ‘Latathera’ may soon be prescribed at general hospitals. According to industry sources, Novartis Korea’s ‘LysaKare (L-arginine hcl/L-lysine hcl) has passed the drug committee (DC) reviews at 3 of the Big 5 general hospitals – Samsung Medical Center, Seoul National University Hospital, Seoul Asan Medical Center - in Korea. LysaKare was approved as a drug to be used concomitantly with Novartis’s orphan drug Lutathera (lutetium), a neuroendocrine tumor treatment that was approved in July 2020. Lutathera is a radioactive targeted therapy that increases the dose of radiation in the tumor areas. It is an ultra-high-priced but highly effective drug used to treat a very small number of patients. The drug was listed for insurance benefit in March last year and cost ₩104 million for 4 injections before then. LysaKare is used to reduce damage caused by renal radiation exposure during the use of Lutathera. The Ministry of Food and Drug Safety had also designated LysaKare as an orphan drug recently. Specifically, LysaKare is indicated for ‘reduction of renal radiation exposure during peptide-receptor radionuclide therapy (PRRT) with lutetium (177Lu) oxodotreotide in adults.’ Meanwhile, Lutathera’s efficacy had been demonstrated through the Phase III NETTER-1 trial and Phase I/II ERASMUS studies. The primary efficacy endpoint of the NETTER-1 study was progression-free survival (PFS). At the time of primary analysis, the median PFS was not reached for Lutathera and was 8.4 months for the control group, showing that Lutathera reduced disease progression and death by 82% compared to the control group. In particular, the drug had significantly prolonged PFS in patients regardless of tumor size, including those with liver tumors, and demonstrated the possibility of effectively treating various types of patients.
Company
HK inno.N's K-CAB has ended Phase 1 in US
by
Kim, Jin-Gu
Apr 11, 2022 05:58am
HK inno.N announced on the 7th that its flagship drug, "K-CAB (Tegoprazan), has successfully ended phase 1 clinical trials in the U.S., a treatment for gastroesophageal reflux disease. The clinical trial was conducted on 30 healthy adults with random assignment, double blinding, placebo control, and repeated administration. K-CAB 25 mg, 50 mg, and 100 mg were administered to clinical participants orally for 7 days, respectively, and pharmacokinetic characteristics and safety were evaluated. As a result of pharmacokinetic evaluation, the blood concentration of K-CAB was proportional according to the content, and similar profiles were maintained on both the 1st and 7th days of administration. In the pharmacological evaluation to measure the acidity (pH) in the stomach, both the 1st and 7th days of administration showed higher acidity than the placebo for 24 hours. In particular, it showed rapid medicinal effects regardless of the dose on the first day of administration. In terms of safety, all doses of K-CAB did not differ from placebo. HK inno.N has been conducting a phase 1 clinical trial of K-CAB with the aim of entering the U.S., the world's largest pharmaceutical market. HK inno.N signed a technology export contract worth about 640 billion won to Braintree Laboratories, a subsidiary of Sebela, a U.S. digestive medicine company, last year when it was undergoing local clinical trials. HK inno.N explained that Braintree Laboratories will be in charge of follow-up clinical trials in the United States and Canada. Braintree Laboratories plans to carry out follow-up clinical trials in the U.S. and Canadian markets as soon as possible. Starting with the smooth completion of the phase 1 clinical trial in the U.S., It will work closely with our local partners to ensure that the Korean new drug K-CAB can be successfully launched in the U.S. market, said Kwak Dal-won, CEO of HK inno.N. K-CAB recorded 109.6 billion won in outpatient prescriptions in Korea last year. Cumulative prescriptions amount to 236.4 billion won over the three years after release. Based on its domestic success, HK inno.N is actively seeking overseas expansion. It has made inroads into 27 countries around the world, including the U.S. In the Chinese market, Luoxin, a local partner, is planning to license and release items in the first half of this year.
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